Résumé : Rieng (Alpinia galanga (L.) Willd) and Diep Ca (Houttuynia cordata Thunb.) are two aromaticplants widely used as spices in Vietnamese cuisine. Numerous studies have reported thatthese plants exhibit various significant bioactivities, including antibacterial, antioxidant, anti-inflammatory and antidiabetic properties. A comparative evaluation of the extraction methodsshowed that the enzyme–ultrasound-assisted technique was the most efficient at extractingthese compounds. These findings open up new possibilities for using Rieng and Diep Ca inVietnam to develop functional foods and treat certain chronic diseases.