Résumé : Micro pollutants (MPs) can be defined as inorganic and organic substances present atlow concentrations (pg/L to ng/L) in the environment, however having adverseconsequences for living organisms even at these low concentrations. To date, aneffective and sustainable global strategy against this insidious contamination of aquaticenvironments barely exists. Source controls and technical systems, such as wastewatertreatment plants, function only as partial barriers or not at all. The enzyme laccase wasidentified as active in the degradation of different MPs. We present data showing thatlaccase from Cerrena unicolor immobilized on mesoporous silica beads(CPC) in acontinuous column reactor, was suitable for elimination of MPs including bisphenolA(BPA), 4-nonylphenol (NP) and triclosan (TCS) . A system equipped with a 3.5 x 0.7cm column packed with immobilized laccase CPC beads (43 Units/g of enzymeactivity), and eluted at 1 mL/min with a solution containing BPA,NP and TCS eachat50 μM, was able to totally remove the three MPs present in at least 1 L of the solution.These results open the possibility to use immobilized laccase in industrial and domesticprocesses for elimination of harmful MPs.