• Citer

Systematic model identification of complex bioprocesses: Application to a CHO-K1 cell culture

par Haag, Jens E.;Wouwer, Alain Vande;Remy, Marcel;Bogaerts, Philippe
Référence IFAC proceedings volumes, 37, 3, page (97-102)
Publication Publié, 2004

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Modeling and parameter identification are important prerequisites for state estimation and control of complex biological systems in bioengineering. Due to the great variety of cell lines and the rapidity of developments in genetics, biosystems have to be investigated in a fast and efficient way to identify the major metabolic phenomena. This paper proposes a systematic modeling procedure, which enables the description of the most important experimental settings and biological effects in terms of stoichiometry, kinetics and metabolic regulation. This procedure is successfully applied to the real case of a perfused mammalian cell culture of non-transfected CHO-K1 cells in suspension.