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Iodide organification defect in a cold thyroid nodule: Absence of iodide effect on cyclic AMP accumulation

par Demeester, Michel ;Van Sande, Jacqueline ;Dor, Pierre
Référence Clinical endocrinology, 20, 4, page (473-479)
Publication Publié, 1984-04

Article révisé par les pairs

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Résumé :

A follicular adenoma of the thyroid was ‘hot’ one hour after 99mTc pertechnetate administration, but ‘cold’24 h after 131I iodide administration. Incubation of the tissue in vitro demonstrated a defect in iodide binding to proteins that was abolished by addition of an H2O2 generating system. In this tissue iodide failed to inhibit TSH-induced cyclic AMP accumulation. The results show that iodide oxidation is required for its inhibitory action on cyclic AMP accumulation in human thyroid.