par Robberecht, Patrick 
;König, Wolfgang;Deschodt Lanckman, Monique ;De Neef, Philippe ;Christophe, Jean
Référence Life sciences, 25, 10, page (879-884)
Publication Publié, 1979
;König, Wolfgang;Deschodt Lanckman, Monique ;De Neef, Philippe ;Christophe, Jean Référence Life sciences, 25, 10, page (879-884)
Publication Publié, 1979
Article révisé par les pairs
| Résumé : | The specific binding of VIP to guinea pig brain membranes was tested by 1/ the ability of eight VIP and secretin analogs and fragments to inhibit the binding of 125I-VIP and 2/ the capacity of the same peptides to influcence basal and VIP-stimulated adenylate cyclase activities. Among all peptides tested, only VIP, secretin [Val5] secretin, and [Gln9, Asn15] secretin (5-27) were able to inhibit 125I-VIP binding. The adenylate cyclase activity was stimulated by VIP, secretin and [Val5] secretin. [Gln9, Asn15] secretin (5-27) although inactive per se was able to inhibit the VIP-stimulated adenylate cyclase activity competitively. |
