par Dehaye, Jean-Paul 
;Winand, Jacques ;Christophe, Jean
Référence FEBS letters, 219, 2, page (451-454)
Publication Publié, 1987-07
;Winand, Jacques ;Christophe, Jean Référence FEBS letters, 219, 2, page (451-454)
Publication Publié, 1987-07
Article révisé par les pairs
| Résumé : | The muscarinic agonist carbamylcholine stimulated 5-fold 86Rb efflux from preloaded rat parotid acini. Apamin was without effect on this carbamylcholine-induced 86Rb efflux. By contrast, the venom from Leiurus quinquestriatus (a scorpion from Israel) inhibited non-competitively this efflux while being without effect on the carbamylcholine-stimulated 45Ca efflux and amylase release. This heat-resistant inhibitory effect of the venom was destroyed by boiling in the presence of dithiothreitol. These results suggest that the venom from L. quinquestriatus contains a toxin capable to block apamin-insensitive calcium-activated potassium channels in rat parotid acini. © 1987. |
