Article révisé par les pairs
Résumé : 1. In intact rat pancreatic acini, 10 nM bombesin, 100 nM phorbol ester TPA and 10 mM fluoroaluminate increased amylase secretion 5-, 3- and 4-fold respectively. 2. Mepacrine dose-dependently inhibited the response to bombesin and fluoroaluminate but did not affect the response to TPA. 3. In permeabilized acini, mepacrine inhibited the secretory response to GTP gamma S without modifying the response to TPA.