Titre:
  • Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid.
Auteur:Van Antwerpen, Pierre; Dufrasne, François; Lequeux, Mathieu; Zouaoui Boudjeltia, Karim; Lessgyer, I.; Babar, Sajida; Moreau, Patrick; Moguilevsky, Nicole; Vanhaeverbeek, Michel; Ducobu, Jean; Neve, Jean
Informations sur la publication:European journal of pharmacology, 570, 1-3, page (235-243)
Statut de publication:Publié, 2007-09
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Chronic inflammatory syndromes
Compound II
Flufenamic acid
Human myeloperoxidase
LDL
Non-steroidal anti-inflammatory drugs
MeSH keywords:Anti-Inflammatory Agents, Non-Steroidal -- metabolism
Cell Line
Chlorine -- metabolism
Cholesterol, LDL -- metabolism
Endothelial Cells -- metabolism
Flufenamic Acid -- metabolism
Humans
Hydrogen Peroxide -- metabolism
Hypochlorous Acid -- metabolism
Oxidation-Reduction
Peroxidase -- antagonists & inhibitors
Peroxidase -- metabolism
Recombinant Proteins -- metabolism
Note générale:Journal Article
Langue:Anglais
Identificateurs:urn:issn:0014-2999
info:doi/10.1016/j.ejphar.2007.05.057
info:pii/S0014-2999(07)00658-9
info:scp/34547837573
info:pmid/17610876