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Reduced cholecystokinin levels in cerebrospinal fluid of parkinsonian and schizophrenic patients. Effect of ceruletide in schizophrenia

par Lotstra, Françoise ;Verbanck, Paul ;Gilles, Christian;Mendlewicz, Julien ;Vanderhaeghen, Jean-Jacques
Référence Annals of the New York Academy of Sciences, 448, page (507-517)
Publication Publié, 1985-07

Article révisé par les pairs

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Résumé :

The preliminary double-blind cross-over study does not indicate that ceruletide exerts antipsychotic action on schizophrenic patients free from neuroleptics. Because schizophrenia is an heterogenous disorder, a differential response to ceruletide in certain subtypes (particularly in acute cases) cannot be excluded at the present stage. A reduction of CCK levels is reported in the CSF of parkinsonian and schizophrenic patients free of neuroleptics. A double-blind cross-over study does not show that ceruletide has antipsychotic properties in neuroleptic-free patients suffering from schizophrenia.