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Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor.

par Hepburn, Anne ;Demolle, Dominique;Boeynaems, Jean-Marie ;Fiers, Walter;Dumont, Jacques Emile
Référence FEBS letters, 227, 2, page (175-178)
Publication Publié, 1988-01

Article révisé par les pairs

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Résumé :

Tumor necrosis factor (TNF) has been shown to induce the phosphorylation of a 27 kDa protein in a time- and concentration-dependent manner in HeLa D98/AH2, ME 180 and bovine aortic endothelial cells. This phosphorylation could be reproduced by the calcium ionophore, A23187. However, this phosphorylation was not observed in L929 cells, for which TNF is highly cytotoxic, suggesting that it might play a role in actions of TNF other than the induction of cell death.