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Demonstration of spontaneous XX/XY chimerism by DNA fingerprinting.

par Farber, Claire ;Georges, M.;De Bock, G.;Verhest, Alain;Simon, Philippe ;Verschraegen-Spae, M;Vassart, Gilbert
Référence Human genetics, 82, 2, page (197-198)
Publication Publié, 1989-05

Article révisé par les pairs

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Résumé :

The M13 bacteriophage probe, which makes possible the establishment of DNA fingerprints, was used to study a phenotypically normal woman with a 46XY karyotype and her twin brother. Identical fingerprints and positive hybridization with a series of Y-specific probes were obtained on blood samples from the siblings. DNA from a skin biopsy of the woman yielded a clearly different pattern and displayed no Y-specific hybridization, indicating that she is a spontaneous chimera. This study illustrates the use of DNA fingerprinting as a powerful and simple aid to the diagnosis of natural chimerism.