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Astrocytic localization of the messenger RNA encoding the isoenzyme B of inositol (1,4,5) 3-kinase in the human brain.

par Mailleux, Pierre ;Takazawa, Kazunaga;Albala, N;Erneux, Christophe ;Vanderhaeghen, Jean-Jacques
Référence Neuroscience letters, 148, 1-2, page (177-180)
Publication Publié, 1992-12

Article révisé par les pairs

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Résumé :

The calcium-mobilizing second messenger inositol 1,4,5-trisphosphate (InsP3) is phosphorylated to inositol 1,3,4,5-tetrakisphosphate, another putative second messenger, through the activity of the enzyme InsP3 3-kinase. The cDNAs encoding two such isozymes have been recently isolated from a human hippocampal cDNAs library. We have previously reported the neuronal localization of the A form (Mailleux et al., Neurosci. Lett., 137 (1992) 69-71) and we here demonstrate the presence of the messenger RNA for the B form in human astrocytes.