Demonstration of prolactin at the ultrastructural level in a pituitary adenoma by the use of colloidal gold labelling.

Brion, Jean Pierre; Couck, A M; Flament Durand, Jacqueline; D'haens, Jean-Henri; Mockel, J

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Demonstration of prolactin at the ultrastructural level in a pituitary adenoma by the use of colloidal gold labelling.

par Brion, Jean Pierre

;Couck, A M ;Flament Durand, Jacqueline

;D'haens, Jean-Henri

;Mockel, J
Référence Journal of submicroscopic cytology, 16, 3, page (555-560)
Publication Publié, 1984-07

Article révisé par les pairs

Résumé :

A prolactin-secreting pituitary adenoma was removed in a 38-year-old man. The tumor was classified as a chromophobe adenoma on the basis of tinctorial staining, but immunocytochemistry revealed that cells reacted with anti-PRL serum. Electron microscopy showed secretory granules and evidence of high metabolic activity (well developed Golgi apparatus and rough endoplasmic reticulum). Immunoelectron microscopy by the immunogold staining method allowed a clear definition of prolactin containing granules.

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