Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats.

Streel, Emmanuel; Dan, Bernard; Bredas, Philippe; Clément, B.; Pelc, Isidore; Verbanck, Paul

doi:doi/10.1016/S0024-3205(01)01429-1

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Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats.

par Streel, Emmanuel

;Dan, Bernard

;Bredas, Philippe ;Clément, B.;Pelc, Isidore

;Verbanck, Paul

Référence Life sciences, 70, 5, page (517-522)
Publication Publié, 2001-12

Article révisé par les pairs

Résumé :

We hypothesized that interference of opiate antagonist-precipitated withdrawal signs under anesthesia is anesthetic-specific. Three groups of morphine-dependent rats were compared in different experimental conditions using a protocol of rapid withdrawal induction by an antagonist under anesthesia. We observed that ketamine and midazolam have different effects on the expression of withdrawal. This brings specific insights into the pharmacological basis of therapy with induction of opiate antagonist.

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