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Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults.

par Ota, M O;Vekemans, Johan;Schlegel-Haueter, Susanna E;Fielding, Katherine;Whittle, Hilton;Lambert, Paul-Henri;McAdam, K P;Siegrist, Claire-Anne;Marchant, Arnaud
Référence Vaccine, 22, 3-4, page (511-519)
Publication Publié, 2004-01

Article révisé par les pairs

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Résumé :

New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.