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The yeast ARGRII regulatory protein has homology with various RNases and DNA binding proteins.

par Messenguy, Francine ;Dubois, Evelyne
Référence Molecular & general genetics : MGG, 211, 1, page (102-105)
Publication Publié, 1988-01

Article révisé par les pairs

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Résumé :

Three regulatory proteins are involved in the post-transcriptional control of arginine metabolism in Saccharomyces cerevisiae: ARGRI, ARGRII and ARGRIII. The 880 amino acid ARGRII protein, like some DNA binding proteins, possesses in its N-terminal sequence a cysteine-rich region that presents homology to the zinc binding region of Escherichia coli aspartate transcarbamylase. ARGRII also has a region of 90 amino acids that is 30% homologous to the E. coli ARGR repressor. Moreover a 87 amino acid long sequence of ARGRII contains three stretches with significant homology to some viral, bacterial and pancreatic RNases. We propose a model in which the RNase-like sequence could regulate the expression of arginine anabolic messenger RNAs.