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Transient ER stress cell-autonomously promotes beta cell cycling in mice.

par Bourgeois, Stephanie;Van Mulders, Annelore;Heremans, Yves;Leuckx, Gunter;Willems, Lien;Coenen, Sophie;Degroote, Laurent;Pierreux, Julie;Kancheva, Daliya;Scheyltjens, Isabelle;Movahedi, Kiavash;Carlotti, Françoise;de Koning, Eelco;Yi, Xiaoyan ;Vinci, Chiara;Tong, Yue ;Cnop, Miriam ;Heimberg, Harry;De Leu, Nico;Staels, Willem
Référence Diabetologia, 69, 5, page (1265-1281)
Publication Publié, 2026-05

Article révisé par les pairs

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Résumé :

Regenerating endogenous pancreatic beta cells is a potentially curative yet currently elusive strategy for diabetes therapy. Mimicking the microenvironment of the developing pancreas and leveraging vascular signals that support pancreatic endocrinogenesis may promote beta cell regeneration. We aimed to investigate whether recovery from experimental hypovascularisation of the endocrine pancreas could trigger mouse beta cell proliferation.