Titre:
  • Transient ER stress cell-autonomously promotes beta cell cycling in mice.
Auteur:Bourgeois, Stephanie; Van Mulders, Annelore; Heremans, Yves; Leuckx, Gunter; Willems, Lien; Coenen, Sophie; Degroote, Laurent; Pierreux, Julie; Kancheva, Daliya; Scheyltjens, Isabelle; Movahedi, Kiavash; Carlotti, Françoise; de Koning, Eelco; Yi, Xiaoyan; Vinci, Chiara; Tong, Yue; Cnop, Miriam; Heimberg, Harry; De Leu, Nico; Staels, Willem
Informations sur la publication:Diabetologia, 69, 5, page (1265-1281)
Statut de publication:Publié, 2026-05
Sujet CREF:Sciences bio-médicales et agricoles
Endocrinologie
Métabolisme
Mots-clés:Beta cell proliferation
Diabetes
Endoplasmic reticulum stress
Glucose-dependency
Single-cell RNA sequencing
Unfolded protein response
Vascularisation
sFLT1
MeSH keywords:Animals
Insulin-Secreting Cells -- metabolism -- cytology
Mice
Mice, Transgenic
Cell Proliferation -- physiology -- genetics
Endoplasmic Reticulum Stress -- physiology -- genetics
Doxycycline -- pharmacology
Cell Cycle -- physiology -- genetics
Vascular Endothelial Growth Factor A -- metabolism
Vascular Endothelial Growth Factor Receptor-1 -- metabolism -- genetics
Male
Signal Transduction
Islets of Langerhans -- metabolism
Langue:Anglais
Identificateurs:urn:issn:0012-186X
info:doi/10.1007/s00125-025-06649-3
info:pii/10.1007/s00125-025-06649-3
info:pmid/41537777
PMC13005877