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Group A Streptococcus adaptation to diverse niches: lessons from transcriptomic studies

par Schiavolin, Lionel ;Deneubourg, Geoffrey ;Steinmetz, Jenny ;Smeesters, Pierre R.;Botteaux, Anne
Référence Critical reviews in microbiology, page (1-25)
Publication Publié, 2023-12-01

Article révisé par les pairs

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Résumé :

Group A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, among others -omics technologies, in addition to traditional molecular methods, has led to a better understanding of GAS pathogenesis and host adaptation mechanisms. This review focusing on bacterial transcriptomic provides new insight into gene-expression patterns in vitro, ex vivo and in vivo with an emphasis on metabolic shifts, virulence genes expression and transcriptional regulators role.