• Citer

A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells.

par Strandmark, Julia;Darboe, Alansana;Diray-Arce, Joann;Ben-Othman, Rym;Vignolo, Sofia SM;Rao, Shun;Smolen, Kinga ;Leroux-Roels, Geert;Idoko, Olubukola T;Sanchez-Schmitz, Guzmán;Ozonoff, Al;Levy, Ofer;Kollmann, Tobias R;Marchant, Arnaud ;Kampmann, Beate
Référence Frontiers in immunology, 13, page (1043375)
Publication Publié, 2022-11-01

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4+ T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4+ T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154+IL-2+TNFα+ CD4+ T-cells following a single birth-dose of HepB in a proportion of infants. Frequencies of polyfunctional T-cells increased following the completion of the HepB schedule but increases in the proportion of responders as compared to following only one dose was marginal. Polyfunctional T-cells correlated positively with serum antibody titres following the birth dose (day30) and completion of the 3-dose primary HepB vaccine series (day 128). These data indicate that a single birth dose of HepB provides immune priming for both antigen-specific B- and T cells.