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Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.

par Azarkan, Mohamed ;Maquoi, Erik;Delbrassine, François;Herman, Raphael;M'Rabet, Nasiha ;Calvo Esposito, Rafaèle ;Charlier, Paulette;Kerff, Frédéric
Référence Scientific reports, 10, 1, page (19570)
Publication Publié, 2020-10-01

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Titre:	Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Auteur:	Azarkan, Mohamed; Maquoi, Erik; Delbrassine, François; Herman, Raphael; M'Rabet, Nasiha; Calvo Esposito, Rafaèle; Charlier, Paulette; Kerff, Frédéric
Informations sur la publication:	Scientific reports, 10, 1, page (19570)
Statut de publication:	Publié, 2020-10-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Ananas -- chemistry
	Antineoplastic Agents, Phytogenic -- chemistry -- pharmacology
	Bromelains -- antagonists & inhibitors -- chemistry -- metabolism -- pharmacology
	Catalytic Domain
	Cell Line, Tumor
	Cysteine -- chemistry
	Cysteine Endopeptidases -- chemistry -- metabolism -- pharmacology
	Cysteine Proteinase Inhibitors -- chemistry -- metabolism
	Disulfides -- chemistry
	Humans
	Leucine -- analogs & derivatives -- chemistry -- metabolism
	Models, Molecular
	Plant Stems -- chemistry
	Protein Conformation
	Spectrometry, Mass, Electrospray Ionization
	Substrate Specificity
	Tosyllysine Chloromethyl Ketone -- chemistry -- metabolism
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:2045-2322
	info:doi/10.1038/s41598-020-76172-5
	info:pii/10.1038/s41598-020-76172-5
	info:scp/85095827118
	info:pmid/33177555
	PMC7658999