Titre:
  • Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Auteur:Azarkan, Mohamed; Maquoi, Erik; Delbrassine, François; Herman, Raphael; M'Rabet, Nasiha; Calvo Esposito, Rafaèle; Charlier, Paulette; Kerff, Frédéric
Informations sur la publication:Scientific reports, 10, 1, page (19570)
Statut de publication:Publié, 2020-10-01
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Ananas -- chemistry
Antineoplastic Agents, Phytogenic -- chemistry -- pharmacology
Bromelains -- antagonists & inhibitors -- chemistry -- metabolism -- pharmacology
Catalytic Domain
Cell Line, Tumor
Cysteine -- chemistry
Cysteine Endopeptidases -- chemistry -- metabolism -- pharmacology
Cysteine Proteinase Inhibitors -- chemistry -- metabolism
Disulfides -- chemistry
Humans
Leucine -- analogs & derivatives -- chemistry -- metabolism
Models, Molecular
Plant Stems -- chemistry
Protein Conformation
Spectrometry, Mass, Electrospray Ionization
Substrate Specificity
Tosyllysine Chloromethyl Ketone -- chemistry -- metabolism
Langue:Anglais
Identificateurs:urn:issn:2045-2322
info:doi/10.1038/s41598-020-76172-5
info:pii/10.1038/s41598-020-76172-5
info:pmid/33177555
PMC7658999