par Gevaert, Andreas B;Shakeri, Hadis ;Leloup, Arthur J;Van Hove, Cor E;De Meyer, Guido R Y;Vrints, Christiaan Jm;Lemmens, Katrien;Van Craenenbroeck, Emeline M
Référence Circulation. Heart Failure, 10, 6
Publication Publié, 2017-06
Référence Circulation. Heart Failure, 10, 6
Publication Publié, 2017-06
Article révisé par les pairs
Résumé : | Because of global aging, the prevalence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains incompletely understood, endothelial inflammation is stated to play a central role. Cellular senescence is a process of cellular growth arrest linked with aging and inflammation. We used mice with accelerated aging to investigate the role of cellular senescence in HFpEF development. |