Thèse de doctorat
Résumé : This thesis aimed to establish how different HLA genotypes correlate to MS severity and disease progression and whether they could be used as additional disease biomarkers and to a large extent the work has succeeded in this task. Association of MS with the alleles HLA-DRB1*15 and HLA-DQB1*06 and haplotype DRB1*15-DQB1*06 was identified, and under representation of other alleles, such as the HLA-DRB1*07 and HLA-A*02 alleles, showed a potentially protective role against the disease. HLA-A*02 was shown to be a marker of a better prognosis and, in contrast, HLA-B*07, B*08 and B*44 seem to be associated to with a worse prognosis.