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Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster

par Jan, Yuh Nung;Ghysen, Alain ;Christoph, I.;Barbel, Sandra;Jan, Lily Yen
Référence The Journal of neuroscience, 5, 9, page (2453-2464)
Publication Publié, 1985

Article révisé par les pairs

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Résumé :

We have followed the formation of neuronal pathways in different imaginal discs of Drosophila. The pattern is highly reproducible for a given disc type but distinct for each type of discs: in leg discs, several neurons are present before metamorphosis and provide two major pathways that are joined by lateral neurons; in the wing and haltere discs, a few pairs of neurons appear after the onset of metamorphosis and pioneer the majority pathways; in antenna discs, no pioneers are detected before massive neuronal differentiation begins. The mechanisms used for axonal guidance seem common to all discs, and the differences between discs can be accounted for simply by differences in the arrangement and birth time of pioneer neurons. Different subsets of pioneer neurons are deleted by mutations such as scute and engrailed.