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A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models.

par Boumendjel, Ahcène;McLeer-Florin, Anne;Champelovier, Pierre;Allegro, Diane;Muhammad, Dima;Souard, Florence ;Derouazi, Madiha;Peyrot, Vincent;Toussaint, Bertrand;Boutonnat, Jean
Référence BMC cancer, 9, page (242)
Publication Publié, 2009-07

Article révisé par les pairs

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Résumé :

Over the past decades, in spite of intensive search, no significant increase in the survival of patients with glioblastoma has been obtained. The role of the blood-brain barrier (BBB) and especially the activity of efflux pumps belonging to the ATP Binding Cassette (ABC) family may, in part, explain this defect.