Article révisé par les pairs
Résumé : Introduction: The transition from pediatric to adult care is at high risk of morbidity and mortality, especially for young adults with sickle cell disease (SCD). We studied the outcome of patients beyond the transition and looked if it was associated with changes in complications and treatments. Patients and methods: This study is focusing on sickle cell disease patients, born after January 1th 1980 and who were followed in paediatrics at HUDERF then in adult care at CHU-Brugmann for at least two years. Patients' data (demographic, genotype, therapies, biological and clinical data, acute clinical event, 6 minutes-walk test, cardiac echography) were analysed before and after the transition from paediatric to adult care. Results: Thirty eight patients were included. The number of acute events and hospitalizations were not statistically different between both periods. Haematological data were similar but creatinine level which increased significantly. The hydroxyurea intake remains stable in time. However, cardio-vascular parameters worsen (tricuspid regurgitation velocity and blood pressure increased significantly over the time and the 6 minutes-walk distance decreased). Two patients died after transition period. Conclusion: Unlike what is described in literature, we didn't notice any increase in acute events nor hospitalizations after the transition period. It seems that progressive cardio-vascular worsening might not be prevented despite a frequent use at recommended dose of hydroxyurea. Those results underlight the quality of transition system in place in this chronic degenerative disease for which new therapeutic approaches are in development.

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