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Polymerization and formation of insoluble byproducts of diclofenac using Trametes versicolor laccases – Experimental study and modelling

par Pype, Rosalie ;Septavaux, Jean ;Oulad Haj Amar, Badredine;Debaste, Frédéric
Référence Journal of Water Process Engineering, 32, 100948
Publication Publié, 2019-12-01

Article révisé par les pairs

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Résumé :

Diclofenac (DCF), a non-steroidal anti-inflammatory drug, is known to be degraded by some laccases. The degradation mechanisms involved when DCF is oxidized by Trametes versicolor laccases was studied with a special focus on the formation of brown-colored insoluble byproducts (IBs) that were suspected to be oligomers. A kinetic study of DCF degradation and IBs formation was performed and a phenomenological kinetic model, based on radical polymerization, was deduced. The model was able to accurately describe both DCF degradation and IBs formation as well as the impact of the polymerization reaction on the degradation rate. That impact was found to be particularly important at high DCF concentrations.