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Status of research and development of vaccines for Streptococcus pyogenes.

par Steer, Andrew C;Carapetis, Jonathan Rhys;Dale, James B;Fraser, John D;Good, Michael F;Guilherme, Luiza;Moreland, Nicole J;Mulholland, Edward Kim Im E.K.;Schodel, Florian;Smeesters, Pierre
Référence Vaccine, 34, 26, page (2953-2958)
Publication Publié, 2016-06

Article révisé par les pairs

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Résumé :

Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates.