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Effects of a gonadotropin-releasing hormone (GnRH) analogue (A-43818) on7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Histological and endocrine studies

par Danguy, André ;Legros, Nicole;Stiennon, Jeanine-Anne;Pasteels, Jean Lambert ;Atassi, Ghanem ;Heuson, Jean-Claude
Référence European journal of cancer, 13, 10, page (1089-1094)
Publication Publié, 1977

Article révisé par les pairs

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Résumé :

The effect of A-43818 [D-leu6 (des-gly-NH10 2, pro-ethylamide9)]-gonadotropin releasing hormone (GnRH) was investigated on rats bearing 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors. Tumor growth was significantly inhibited by the s.c. administration of 10 μg A-43818, twice daily, for six weeks. A dose of 25 μg seemed less effective. Controls and experimental groups were subjected to radioimmunoassays (RIA) of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL), and to histological examination of pituitaries and ovaries. Treatment with A-43818 resulted in atrophy of pituitary lactotropes and decreased prolactin concentration in plasma. Plasma LH levels were enhanced whereas FSH levels remained unchanged. The endocrine mechanisms of inhibition of tumor growth are discussed in the light of the well-known hormone dependance of DMBA-induced mammary tumors. © 1977.