par Gurzov, Esteban Nicolas ;Stanley, William J;Pappas, Evan G;Thomas, Helen H.E.;Gough, Daniel DJ
Référence The FEBS journal, 283, 16, page (3002-3015)
Publication Publié, 2016-08
Référence The FEBS journal, 283, 16, page (3002-3015)
Publication Publié, 2016-08
Article révisé par les pairs
Résumé : | Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes. |