par Truyens, Carine 
;Carlier, Yves
Editeur scientifique Telleria, Jenny;Tibayrenc, Michel
Référence American Trypanosomiasis Chagas Disease, One Hundred Years of Research, Elsevier, London, Ed. 2, page (579-604)
Publication Publié, 2017
;Carlier, Yves Editeur scientifique Telleria, Jenny;Tibayrenc, Michel
Référence American Trypanosomiasis Chagas Disease, One Hundred Years of Research, Elsevier, London, Ed. 2, page (579-604)
Publication Publié, 2017
Partie d'ouvrage collectif
| Résumé : | The immune response to T. cruzi infection is particularly complex due to the presence, in the host, of both extracellular and intracellular parasites (invading different cell types and tissues), therefore requiring different types of responses. This chapter reviews in depth the innate and adaptive immune mechanisms allowing the host to partially control acute infection, underlying recent advances on innate parasite recognition, and on how the key cytokines IFN-gamma and IL-17 are protective. It also highlights effector and regulatory mechanisms, as well as the immunological disturbances leading to delay the development of an efficient immune response. After the acute phase, the infection evolves in chronic persistence of parasites at low levels. Although differences of susceptibility between hosts and parasite virulence factors contribute to the inability to eliminate the parasite, T. cruzi is endowed with several escape mechanisms which are also described. |
