Article révisé par les pairs
Résumé : In a systematic study, 406 female and 400 male patients admitted to clinical wards for miscellaneous non-thyroid diseases were screened for thyroid antibodies and serum-cholesterol levels. The clinical and laboratory data were analysed by computer. In the female population asymptomatic thyroiditis (i.e., preclinical hypothyroidism) represents an important risk-factor for coronary heart-disease (C.H.D.). It abolishes the well-established sex-ratio for C.H.D. Increased levels of serum-cholesterol may play a part in this pathogenic mechanism. However, an alternative explanation is that a genetic factor may be responsible both for the tendency to develop atherosclerosis and for the lymphocytic thyroiditis. © 1971.