Article révisé par les pairs
Résumé : This paper describes an attempt to derive a new methodology to determine the significance of effects estimated from a screening design, starting from the algorithm of Dong but overcoming its drawbacks. Especially in situations where effect sparsity does not occur and the number of significant effects approaches 50%, the currently often applied algorithm of Dong leads to many important effects incorrectly considered non-significant, i.e. to false negative results. For these situations, a new methodology is recommended. Based on the algorithm of Dong, several alternative approaches were explored and compared. From all approaches, the one using the 75% lowest absolute factor effects to calculate the initial error estimation s(0), i.e. s(0)=1.5 x median