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Growth inhibition of rat mammary carcinoma and endocrine changes produced by 2-Br-α-ergocryptine, a suppressor of lactation and nidation

par Heuson, Jean-Claude ;Van Gaver, Christine ;Legros, Nicole
Référence European journal of cancer, 6, 5, page (353-356)
Publication Publié, 1970

Article révisé par les pairs

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Résumé :

Administration of 2-Br-α-ergocryptine for 6 weeks to Sprague-Dawley rats bearing DMBA-induced mammary carcinomas increased the number of regressing tumors and decreased the incidence of newly-formed ones. This inhibitory effect on tumor growth was highly significant. In addition, the drug produced the following endocrine changes: shortening of the estrus cycle and accumulation of large numbers of corpora lutea, which seemed inactive with respect to secretion of progestational compounds and did not undergo normal involution. It is suggested that these effects, both on tumor growth and on endocrine functions, probably resulted from interference with prolactin secretion. © 1970.