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In vivo effect of ultrasound at human therapeutic doses on marrow cell chromosomes of golden hamster

par Levi, Salvator ;Gustot, Pierre ;Galperin, Hélène
Référence Humangenetik, 25, 2, page (133-141)
Publication Publié, 1974

Article révisé par les pairs

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Résumé :

Ultrasounds are widely used in therapy and diagnosis, particularly for obstetrical diagnosis. Studies of their biological effects were recently focused on chromosomes and the results were contradictory. Because of possible artefacts due to tissue culture stages, in vivo insonation of bone marrow cells has been performed at 1 and 1.5 W/cm2 and 0.87 MHz frequency for 2 to 5 min, at much higher doses than used for human fetus investigation. Colchicine was injected in vivo 1 hr before cell harvesting and chromosomes were examined immediately afterward. A study of 1503 mitoses from 20 animals was made. No statistically significant differences in aberration rate were observed between insonated and control cells. (44 references)