par Manicourt, Daniel 
;Chochrad, Isidore ;Orloff, Serge
Référence Acta rhumatologica, 2, 1-2, page (34-44)
Publication Publié, 1978
;Chochrad, Isidore ;Orloff, Serge Référence Acta rhumatologica, 2, 1-2, page (34-44)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | Total hydroxypoline, an index of collagen metabolism, was estimated in synovial fluid of patients with rheumatoid arthritis (RA), chondrocalcinosis and osteorthrosis; these data are compared to other parameters usually studied in synovial fluid (total proteins, cytology), to sytemic indices of inflammation and to urinary hydroxyproline in RA patients; in these patients the present study confirms the linear regression line between synovial hydroxyproline and sedimentation rate providing thus a new index of the degree of local inflammation. Furthermore in the same patients a highly significant correlation is found between synovial hydroxyproline and lymphocyte counts stressing the role the latter play in allowing an estimate of the destructive potential of the disease. Similar correlations are not found in chondrocalcinosis where synovial hydroxyproline is correlated with the polymorphonuclear counts who are known to exhibit collagenolytic activity. No such correlation could be found in osteoarthrosis. Finally the correlation found between synovial and urinary hydroxyproline casts a light upon the interpretation of the latter parameter in patients with R.A. |
