Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease

Lunardi-Yskandar, Yanto; Bryant, Joseph L.; Blattner, William; Hung, Chia Ling; Flamand, Louis; Gill, Parkash; Hermans, Philippe; Birken, Steven; Gallo, Robert C.

doi:doi/10.1038/nm0498-428

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Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease

par Lunardi-Yskandar, Yanto ;Bryant, Joseph L.;Blattner, William ;Hung, Chia Ling ;Flamand, Louis ;Gill, Parkash ;Hermans, Philippe

;Birken, Steven ;Gallo, Robert C.
Référence Nature medicine, 4, 4, page (428-434)
Publication Publié, 1998-04

Article révisé par les pairs

Résumé :

The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcona HIV, SIV and hematopoiesis were examined in vitro and ip vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factor (HAF) with anti-HIV, anti-SIV, anti-KS and pro-hematopoietic activities elutes as two peaks corresponding to 15-30 kDa and 2-4 kDa.

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