par Mokrim, Maha ;Aftimos, Philippe ;Errihani, Hassan;Piccart-Gebhart, Martine
Référence BMJ case reports
Publication Publié, 2014-04
Référence BMJ case reports
Publication Publié, 2014-04
Article révisé par les pairs
Résumé : | Despite many treatment advances, metastatic breast cancer remains an incurable disease and is the third leading cause of cancer-related deaths in Europe. Capecitabine has become a standard treatment option for metastatic breast cancer, as a single agent or in combination. Hand-foot syndrome and diarrhoea are the most frequently reported side effects, while capecitabine-related ileitis is very rare. Deficiency of dihydropyrimidine dehydrogenase activity leads to severe toxicities after administration of 5-fluorouracil or its prodrugs. We report two cases of patients with metastatic breast cancer who developed ileitis after treatment with capecitabine. One patient had a DPYD gene abnormality. Copyright 2014 BMJ Publishing Group. All rights reserved. |