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Pathological implication of postnatally up-regulated AFP expression in ZBTB20 knockout neonatal mice

par Zhang, Hai;Xie, Zhi-Fang;Szpirer, Claude ;Zhang, Wei-Ping
Référence Di-Er Jun-Yi Daxue xuebao, 31, 10, page (1045-1048)
Publication Publié, 2010-10

Article révisé par les pairs

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Résumé :

Objective: To investigate the pathological roles of postnatally up-regulated alpha-fetoprotein (AFP) expression in ZBTB20 knockout mice in postnatal growth retardation, metabolic dysfunction, and pre-mature mortality. Methods: ZBTB20 and AFP knockout mice were generated by crossbreeding ZBTB20 knockout mice with AFP knockout mice. The postnatal growth, survival rate, and blood glucose of ZBTB20/AFP double knockout mice were observed and compared with those of ZBTB20 knockout mice. Results: There were no significant differences in postnatal growth, survival, and glucose homeostasis between ZBTB20/AFP doube knockout mice and ZBTB20 knockout mice. Conclusion: The postnatally upregulated liver AFP in ZBTB20 knockout mice is not associated with the growth retardation, hypoglycemia, or pre-mature mortality.