par Balasse, Edmond 
;Fery, Françoise
Référence Nutrition clinique et métabolisme, 7, 3, page (211-217)
Publication Publié, 1993
;Fery, Françoise Référence Nutrition clinique et métabolisme, 7, 3, page (211-217)
Publication Publié, 1993
Article révisé par les pairs
| Résumé : | The ketone bodies which result from the partial oxidation of fatty acids in the liver, play an important physiological role in energy homeostasis. During prolonged fasting, they are taken up and oxidized by the brain thus allowing for a reduction in glucose utilization by this organ. This process is facilitated by a saturation of the capacity of muscle to take up ketone bodies at high concentration. The ketone body concentration is remarkably steady when the duration of the fast exceeds 7-10 days. This phenomenon is related to the fact that ketone bodies tend to inhibit their own production as a result of their stimulatory effect on insulin secretion and their inhibitory action on adipose tissue lipolysis. During diabetic ketosis, this regulatory process is not operative due to the lack of insulin secretion. It has been hypothesized that ketone bodies could be instrumental in the protein sparing process known to occur during prolonged fasting. Most of the experimental data published on this subject could not confirm this hypothesis and elevated ketone body levels do not prevent the protein wastage that occurs in patients who are in a severe catabolic state. © 1993 Arnette S.A. |
