par Communi, Didier 
;Robaye, Bernard ;Janssens, Rodolphe ;Parmentier, Marc ;Boeynaems, Jean-Marie
Référence Drug development research, 45, 3-4, page (130-134)
Publication Publié, 1998
;Robaye, Bernard ;Janssens, Rodolphe ;Parmentier, Marc ;Boeynaems, Jean-Marie Référence Drug development research, 45, 3-4, page (130-134)
Publication Publié, 1998
Article révisé par les pairs
| Résumé : | The cloning of P2Y4 and P2Y3 (chicken)/P2Y6 (rat, human) receptors has been the ultimate proof that receptors for pyrimidine nucleotides exist. However, on the basis of their structure these receptors do not constitute a family of their own but belong to the P2Y family, which thus encompasses selective purinoceptors (P2Y1, P2Y11), nucleotide receptors responsive to both adenine and uracil nucleotides (P2Y2, P2Y8), and pyrimidinoceptors (P2Y4 responsive to UTP, P2Y3/P2Y6 responsive to UDP). Although the occurrence of uracil nucleotides in extracellular fluids remains poorly documented, the very existence of P2Y receptors selectively responsive to them strongly suggests that UTP and UDP may play a role as intercellular mediators, independently from adenine nucleotides. Northern blotting revealed an expression of the P2Y6 receptor mRNA in human spleen, thymus, and blood leukocytes, as well as in Jurkat and MOLT-4 T-cell lines. Other experiments revealed an expression in 1HAEo and 16HBE14o cell lines derived from the airway epithelium. These studies suggest a possible role of the P2Y6 receptor in the immune and respiratory systems. |
