par Devos, Philippe;Chioléro, René;Van den Berghe, Greet;Preiser, Jean-Charles
Référence Current opinion in clinical nutrition and metabolic care, 9, 2, page (131-139)
Publication Publié, 2006-03
Article révisé par les pairs
Résumé : The importance of glucose metabolism and insulin therapy during myocardial ischaemia is increasingly being investigated. Insulin is used to achieve a tight glucose control or as part of glucose-insulin-potassium therapy. We have reviewed (1) the physiological and physiopathological consequences of hyperglycaemia focusing on potential machanisms of myocardial ischaemia, (2) the effects of insulin on vascular tone, on the release of free fatty acids, on inflammatory pathways, on the switch of energy source and on apoptosis, and (3) clinical data reporting the effects of intensive insulin therapy and glucose-insulin-potassium solutions during myocardial ischaemia and ischaemic heart failure.