Résumé : Context. Previous studies have shown that many post-asymptotic giant branch (AGB) stars with dusty disks are associated with single-lined binary stars. The inferred orbital separations are too small to accommodate a fully grown AGB star, hence these systems represent a new evolutionary channel that bypasses a full AGB evolution. Aims. We wish to verify the binarity hypothesis for a larger sample establish the nature of the companions, and probe the disk structure and eventually the disk formation mechanisms in binary stars. To achieve these aims, we started a high-resolution spectral monitoring of ~40 field giants whose binarity had been suspected based on either a light curve, an infrared excess, or a peculiar chemical composition. Methods. Starting from the spring of 2009, we monitored the programme stars with the fibre echelle spectrometer HERMES. We measure their radial velocities (RVs) with a precision of ~0.2 km s -1, perform detailed photospheric abundance analyses, and analyse the time-resolved high-resolution spectra to search for line-profile variability. Results. Here we report on the discovery of periodic RV variations in BD+46°442, a high Galactic latitude F giant with a disk. We infer that the variations are caused by the motion around a faint companion, and deduce the orbital parameters P orb = 140.77 ± 0.02 d,e = 0.083 ± 0.002, and asini = 0.31 AU. We find that it is a moderately metal-poor star ([M/H] =-0.7) without a strong depletion pattern in its photospheric abundances. Interestingly, many lines indeed show periodic changes with the orbital phase: Hα switches between a double-peak emission line and a P Cyg-like profile, while strong metal lines appear to be split at the maximum redshift. Similar effects are likely visible in the spectra of other post-AGB binaries, but their regularity is not always apparent owing to sporadic observations. We propose that these features result from an ongoing mass transfer from the evolved giant to the companion. In particular, the blue-shifted absorption in Hα, which occurs only at superior conjunction, may result from a jet originating in the accretion disk around the companion and that is seen in absorption towards the luminous primary. © 2012 ESO.