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A photoreactive ruthenium(II) complex tethered to a guanine-containing oligonucleotide: a biomolecular tool that behaves as a "Seppuku Molecule"

par Le Gac, Stéphane ;Rickling, Stéphane ;Gerbaux, Pascal;Defrancq, Eric;Moucheron, Cécile ;Kirsch-De Mesmaeker, Andrée
Référence Angewandte Chemie, 48, 6, page (1122-1125)
Publication Publié, 2009

Article révisé par les pairs

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Résumé :

(Figure Presented) Self-destruction: Attachment of a photoreactive Ru II complex to a guanine-containing oligonucleotide has led to an innovative biomolecular tool for gene silencing studies. This conjugate can be selectively photo-cross-linked with its complementary strand but undergoes a self-inhibition (or "seppuku") process in the presence of a noncomplementary target (see picture), which is an attractive strategy to avoid undesired secondary photoeffects. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.