Titre :
  • 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
Auteur : de Tullio, Pascal ; Boverie, Stéphane ; Becker, Bénédicte ; Antoine, Marie-Hélène ; Nguyen, Quynh Anh ; Francotte, Pierre ; Counerotte, Stéphane ; Sebille, Sophie ; Pirotte, Bernard ; Lebrun, Philippe
Informations sur la publication : Journal of medicinal chemistry, 48, 15, (page 4990-5000)
Statut de publication : Publié, 2005-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adenosine Triphosphate -- physiology
Animals
Aorta -- drug effects
Aorta -- physiology
Benzothiadiazines -- chemical synthesis
Benzothiadiazines -- chemistry
Benzothiadiazines -- pharmacology
Cyclic S-Oxides -- chemical synthesis
Cyclic S-Oxides -- chemistry
Cyclic S-Oxides -- pharmacology
Insulin -- secretion
Ion Channel Gating
Islets of Langerhans -- drug effects
Islets of Langerhans -- secretion
Muscle Contraction -- drug effects
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- physiology
Organ Specificity
Potassium Channels -- drug effects
Rats
Rats, Wistar
Structure-Activity Relationship
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm0580050
info:pmid/16033278