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3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.

par de Tullio, Pascal;Boverie, Stéphane;Becker, Bénédicte ;Antoine, Marie-Hélène ;Nguyen, Quynh Anh ;Francotte, Pierre;Counerotte, Stéphane;Sebille, Sophie;Pirotte, Bernard;Lebrun, Philippe
Référence Journal of medicinal chemistry, 48, 15, page (4990-5000)
Publication Publié, 2005-07

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Titre:	3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
Auteur:	de Tullio, Pascal; Boverie, Stéphane; Becker, Bénédicte; Antoine, Marie-Hélène; Nguyen, Quynh Anh; Francotte, Pierre; Counerotte, Stéphane; Sebille, Sophie; Pirotte, Bernard; Lebrun, Philippe
Informations sur la publication:	Journal of medicinal chemistry, 48, 15, page (4990-5000)
Statut de publication:	Publié, 2005-07
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- physiology
	Animals
	Aorta -- drug effects
	Aorta -- physiology
	Benzothiadiazines -- chemical synthesis
	Benzothiadiazines -- chemistry
	Benzothiadiazines -- pharmacology
	Cyclic S-Oxides -- chemical synthesis
	Cyclic S-Oxides -- chemistry
	Cyclic S-Oxides -- pharmacology
	Insulin -- secretion
	Ion Channel Gating
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- secretion
	Muscle Contraction -- drug effects
	Muscle, Smooth, Vascular -- drug effects
	Muscle, Smooth, Vascular -- physiology
	Organ Specificity
	Potassium Channels -- drug effects
	Rats
	Rats, Wistar
	Structure-Activity Relationship
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm0580050
	info:scp/22744438406
	info:pmid/16033278