par Camacho, Carlos Camacho;Rojas-Oviedo, I.;Paz-Sandoval, A.;Càrdenas, J.;Toscano, Antonio;Gielen, Marcel 
;Barrón Sosa, L.;Sànchez Bàrtez, F.;Gracia-Mora, I.
Référence Applied organometallic chemistry, 22, 3, page (171-176)
Publication Publié, 2008-03
;Barrón Sosa, L.;Sànchez Bàrtez, F.;Gracia-Mora, I.Référence Applied organometallic chemistry, 22, 3, page (171-176)
Publication Publié, 2008-03
Article révisé par les pairs
| Résumé : | The synthesis, characterization and cytotoxic properties in vitro of tri-n-butyltin 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (1), tri-phenyltin 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (2), tetra-n-butyltin[bis-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetato]distannoxane (3) and di-n-butyltin bis-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (4) are described. These compounds have been characterized by 1H, 13C and 119Sn NMR spectroscopy in solution and 119Sn NMR in the solid state, infrared spectroscopy, elemental analysis and X-ray diffraction for compound 1. The growth inhibition effects of compounds 1–4 against the lung adenocarcinoma cell line SK-LU-1 as well as the cervical cancer cell line HeLa were determined. Compounds 1 and 2 exhibit cytotoxic activity, whereas compounds 3 and 4 are inactive. Copyright © 2008 John Wiley & Sons, Ltd. |
