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Synthesis, characterization and in vitro cytotoxicity of homobimetallic complexes of palladium(II) with 2-thiouracil ligands: Crystal structure of [Pd2(TU)(PPh3)3Cl2]

par Shaheen, F.;Badashah, A.;Gielen, Marcel ;Marchio, L.;De Vos, Danièle ;Khosa, M.K.
Référence Applied organometallic chemistry, 21, 8, page (626-632)
Publication Publié, 2007-08

Article révisé par les pairs

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Résumé :

Square planar metallic and homonuclear bimetallic complexes of Pd(II) with 2-thiouracil (HTU) and organophosphines have been synthesized and characterized by FT-IR and multinuclear 1H, 13C, 31P NMR spectroscopy. The thiouracil ligand TU acts as bidentate, is bound through the thioxo moiety and the endo amino group and forms a bridge between a PdCl(R3P) and a PdCl(R3P)2 moiety [R3P = Ph3P (o-tolyl)3P, ClPh2P] in the homonuclear bimetallic complexes. The square planar geometry around Pd(II) has been confirmed for these complexes by a single-crystal X-ray diffraction study of compound 1, [Pd2(TU)(PPh3)3Cl2]. These compounds were also screened against human tumor cell lines and showed promising in vitro cytotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.