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Di(n-butyl)tin bis(dihydroxybenzoate)s: synthesis, spectroscopic characterization and in vitro antitumour activity

par Gielen, Marcel ;Bouhdid, Abdeslam;Kayser, François;Biesemans, Monique;De Vos, Danièle ;Mahieu, Bernard;Willem, Rudolph
Référence Applied organometallic chemistry, 9, 3, page (251-257)
Publication Publié, 1995-05

Article révisé par les pairs

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Résumé :

Six di(n-butyl)tin(IV) and two dimethyltin(IV) bis-(dihydroxybenzoate)s were synthesized and characterized by 1H, 13C and 119Sn NMR and Mössbauer spectroscopy. Five of the di(n-butyl)tin compounds were screened in vitro against six human tumour cell lines, MCF-7, EVSA-T, WiDr, IGROV, M19 and A498. They are more active than carboplatin, cisplatin and 5-fluorouracil against all cell lines and of comparable activity or better than methotrexate. All dihydroxybenzoates with an ortho-bydroxyl group are more active against MCF-7 cells than substituted salicylates screened previously.