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Di-n-butyltin and diethyltin monofluorobenzoates: Synthesis, spectroscopic characterization and in vitro antitumour activity

par Gielen, Marcel ;El Khloufi, A;Biesemans, Monique;Willem, Rudolph
Référence Applied organometallic chemistry, 7, 2, page (119-125)
Publication Publié, 1993-04

Article révisé par les pairs

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Résumé :

The di-n-butyltin(IV) and diethyltin(IV) fluorobenzoates [FC6H4COO]2SnR2 and (FC6H4COOR2Sn)2O have been synthesized and characterized spectroscopically. Their in vitro antitumor activity against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma, as well as against the NCI cell panel, is satisfactory.